Complex Systems and Mathematical Biology


 I. Coordinator:

Lee-Wei Yang, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, lwyang@life.nthu.edu.tw


II. Core Members:

Lee-Wei Yang, Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Dr Yuan-Haw Chang, Institute of Information Science, Academia Sinica
Dr Jui-Hung Hung, Dept Biological Science and Technology, National Chiao Tung University
Dr Fan-Pei Gloria Yang, Dept. of Foreign Languages and Literature, National Tsing Hua University
Dr Tzay-Ming Hong, Department of Physics, National Tsing Hua University
Dr Sheng-Te Danny Hsu, Institute of Biological Chemistry, Academia Sinica 

III. Major Directions:

Entering the 21st century life science, scientists have gotten used to the techniques and concept such as next generation sequencing (NGS) of human genome, epigenetics, metagenetics, optogenetics, metabolomics, precision medicine, CRISPR/Cas9 (genome editing techniques), brain imaging, computational neuroscience etc. Life is understood in unprecedented details in molecular and cellular levels while more preventive and controlling measures can be put in place to manipulate molecular and cellular behaviors with great clinical interest. On the other hand, life in the behavioral side has not been understood together with these molecular and cellular details. A better understanding in correlation and causality between these two levels of life can be important to promote medicinal, educational and social welfare redistribution, in the scope of promoting a more sustainable community. Human life, its behavior and future can also be better understood by its dynamic environment (the social network an individual is in and epigenetics) and his intrinsic heritage (genetics). Moreover, those understood as personality, character, morality and spirit which greatly shape societies in every generation can also be re-understood and classified at the molecular and cellular levels and from neuron wiring patterns. All these demand new ways of collecting data, new classification of human groups and their diseases and new interdisciplinary collaborations. To address the need of the society, from the center’s point of view, we promote the exchanges in the following area.

   1. Structural and dynamics modeling of biomolecules, cell components and human individuals in different states – This includes but is not limited to advanced structural biology techniques, single molecule techniques, biophysical method development, protein folding and dynamics, biomechanics, neuron contact topology and wiring patterns, molecular evolution and population genetics, systems biology, human behavior prediction and modeling.

   2. Data collection, correlation analysis and pattern recognition – Data collected from social network (multimedia and text), new classification of human behavior using new indices, large-scale network analysis, correlation between gene SNPs and human behavior/personality/character, relation between social behavior, mental disease and epigenetics/genetics/metabolomics, behavior biomarkers, brain imaging analysis coupled with behavior defined by social network, mathematical modeling of social/health/ financial/welfare network.


VI. Activities:

1. Monthly seminar talks at the NCTS at the National Tsing-Hua University campus.
2. Annual meetings/conferences.  Two annual meetings are scheduled thus far in 2017. They are

● Workshop-Challenges in Neuroscience

   Date: 2017.04.14(Fri)
   Place: Lecture Room A of NCTS, 4F, General Building III, NTHU
   Site: http://phys.cts.nthu.edu.tw/actnews/?Sn=337


● Workshop- Advances in Structural Biology and Beyond
   Date: 2017.05.11(Thu)
   Place: Watson Hall, Life Science Building II (morning)
   Lecture Room A of NCTS, 4F, General Building III (afternoon), NTHU
   Site: http://phys.cts.nthu.edu.tw/actnews/?Sn=331 

● Computational Biology Workshop
   Date: 2017.07.29(Sat)
   Place: Lecture Room A of NCTS, 4F, General Building III, NTHU
   Site:  http://phys.cts.nthu.edu.tw/actnews/?Sn=364 

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