:::

Seminars

:::

  • Title:Assessing the Traversal of Natural Compounds through Skin’s Permeability Barrier
  • Start Date/Time:2020-02-19 / 09:30
  • End Date/Time :2020-02-19 / 12:00
    • Speaker:Mr Navaneethan Radhakrishnan
    • Place:清大生科一館R119室
    • Host:Prof. Lee-Wei Yang (NTHU)
    • Abstract:Skin is the largest organ that forms an anatomical barrier between the body and the environment. It is involved in protection; sensory perception; synthesis, storage and excretion of biomolecules; and regulation of homeostasis. Skin is mainly composed of two layers: the epidermis – outer layer, and the dermis – inner layer. The outer layer of epidermis is stratum corneum (SC), which comprises the permeability barrier, and prevents entry of pathogens and loss of water. It is composed of dead cells called corneocytes embedded in a matrix of ceramides, cholesterol and free fatty acids. As skin is directly exposed to environment, its response to environmental factors determines skin characteristics. Solar ultra-violet radiation is the most effectual factor, excessive exposure of which, can lead to sunburn, photoaging, erythema, edema, immune suppression, melanoma and non-melanoma skin cancers. Nature offers a plethora of bioactive compounds, which can be effective counter-active agents, with less side-effects compared to synthetic drugs. With natural compounds being investigated as potential cancer-therapeutic/chemo-preventive/anti-aging/cosmeceutical agents for skin, the study of transport of these drug candidates across skin’s permeability barrier, becomes crucial for topical drug administration. This study aims at studying the traversal of natural compounds through lipid matrix of SC using atomistic molecular dynamics simulations. 

      Abstract

    • Detailed contents: 
    cron web_use_log