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Seminars

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  • Title:Multifunctional Nanocarriers for Efficient Treatment against Hepatocellular Carcinoma with Desmoplasia
  • Start Date/Time:2019-02-25 / 12:00
  • End Date/Time :2019-02-25 / 12:40
    • Speaker:Prof. Yunching Chen (NTHU)
    • Place:Lecture Room A of NCTS, 4F, General Building III, NTHU
    • Host:Prof. Lee-Wei Yang (NTHU)
    • Abstract: Hepatocellular carcinoma (HCC) is characterized as a malignant disease that progresses rapidly, and it is refractory to conventional chemotherapy, as well as molecular targeted therapy. Both intrinsic and acquired resistance to the targeted mono-therapy and unwanted toxicity often develop and restrict the therapeutic efficacy and clinical application of the treatment. In addition, most cases of HCC develop in the presence of liver cirrhosis and chronic inflammation, which fuels HCC growth and influences treatment prognosis. Our aim is to develop targeted nanoparticle (NP) formulation to co-deliver multiple therapeutic agents such as plasmid DNA (pDNA), siRNA or small molecule drugs into both HCC and the surrounding fibrotic liver. The therapeutic agents co-delivered by NPs could target the compensatory activated pathway in the tumor cells and stromal cells in the microenvironment and thus efficiently induce apoptosis in the tumor lesions. We demonstrated that the targeted multifunctional NPs could ameliorate angiogenesis, fibrosis and inflammation in the tumor microenvironment and suppress HCC progression in a clinically relevant HCC model with associated underlying liver fibrosis. To this end, the targeted multifunctional NPs can provide an effective approach for overcoming drug resistance, leading to better therapeutic effects in treating liver cancer.

      Registration: https://docs.google.com/forms/d/e/1FAIpQLSeb9a5RXXexClpdJ84TIf5lDmP-KtT29EEOplRB3lpJ0qSUrA/viewform
    • Detailed contents: Biography
      Dr. Yunching Chen has received her Ph.D. degree in Pharmaceutical Sciences at the University of North Carolina at Chapel Hill in May 2010. She completed her doctoral thesis under the supervision of Dr. Leaf Huang and developed various novel nanoparticle formulations to deliver RNA therapeutics and chemotherapy drugs for cancer therapy. She later worked with Drs. Rakesh Jain and Dan Duda as a research fellow of Radiation Oncology at Harvard Medical School and Massachusetts General Hospital. She found the tumor stroma plays an important role on immunosuppression, drug resistance, and cancer cell survival and metastasis (Hepatology, 2014; PNAS, 2014). She joined the faculty of National Tsing Hua University as a tenure-track Assistant Professor in 2013. She rose through the ranks to Associate Professor in 2016. Her work provides a molecular understanding for the development of effective combination therapeutic approaches for the treatment of cancer (Hepatology, 2015; Nature Protocols, 2015; Biomaterials, 2015; Journal of Controlled Release, 2015; Hepatology, 2018). She has published 31 journal papers with nearly 2900 citations and an h-index of 19.
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